COMPLEMENT C7 DEFICIENT SERUM HUMAN

Application

Complement C7 deficiencies in humans are rare, but often associated with recurrent infections by Neisseria spp. (such as meningitis). C7 deficiencies in patients with meningococcal meningitis have shown a mutation which results in an 11 bp deletion in exon 6 resulting in a premature stop codon. Additionally, research has suggested that screening of patients with systemic neisserial infection by CH50 or the APH-50 assay can reveal a C7 deficiency.

Physical form

Supplied as a solution in PBS, pH 7.4

Analysis Note

C7 is depleted by immunoadsorption as judged by a highly sensitive hemolytic assay.

Disclaimer

RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.

biological source: human. Quality Level: 200. form: solution. technique(s): activity assay: suitable. UniProt accession no.: P10643. shipped in: dry ice. storage temp.: −. 70°C. Gene Information: human ... C7(730). Storage Class Code: 10 - Combustible liquids. WGK: WGK 3. Flash Point(F): Not applicable. Flash Point(C): Not applicable.