COMPLEMENT C5A DES-ARG HUMAN

General description

Native, human des-Arg C5a complement component. Single chain glycopeptide composed of 73 amino acids. Once the C5a glycopeptide has been produced in human plasma or serum, it is rapidly converted to C5a des-Arg upon removal of the C-terminal arginine by the endogenous serum carboxypeptidase N. Unlike the C3a des-Arg peptide, C5a des-Arg retains significant levels of its biological activities. Thus, C5a des-Arg has been shown to exhibit inflammatory cell chemotaxis, smooth muscle contraction, and leukotriene release from guinea pig lung.

Native, human des-Arg C5a complement component. Single chain glycopeptide composed of 73 amino acids. Once the C5a glycopeptide has been produced in human plasma or serum, it is rapidly converted to C5a des-Arg upon removal of the C-terminal arginine by the endogenous serum carboxypeptidase N. Unlike the C3a des-Arg peptide, C5a des-Arg retains significant levels of its biological activities. Thus, C5a-des-Arg has been shown to exhibit inflammatory cell chemotaxis, smooth muscle contraction, and leukotriene release reactions from guinea pig lung.

Packaging

Please refer to vial label for lot-specific concentration.

Warning

Toxicity: Standard Handling (A)

Physical form

In 120 mM NaCl, 10 mM HEPES, pH 7.2.

Preparation Note

Prepared from plasma of individuals that have been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.

Reconstitution

Following initial thaw, aliquot and freeze (-70°C).

Other Notes

Webster, R.O., et al. 1980. Immunopharmacology 1, 201.
McCarthy, K. and Henson, P.M. 1979. J. Immunol. 123, 2511.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Quality Level: 100. Assay: ≥. 90% (SDS-PAGE). form: liquid. manufacturer/tradename: Calbiochem^®. . storage condition: OK to freeze, avoid repeated freeze/thaw cycles. shipped in: wet ice. storage temp.: −. 70°C. Storage Class Code: 12 - Non Combustible Liquids. WGK: nwg. Flash Point(F): Not applicable. Flash Point(C): Not applicable.