COLISTIN METHANESULFONATE SODIUM (C005B-081548)

General description

Chemical structure: peptide

Application

Colistin sodium methanesulfate is used to permeabilize bacterial cell membranes and to study mannose-resistant haemagglutination.

Biochem/physiol Actions

Colistin is a cationic, multicomponent lipopeptide antibiotic. It consists of a cyclic heptapeptide with tripeptide side chain, acylated at the N terminus by a fatty acid. It exhibits a potent anti-endotoxin. Colistin interacts with the anionic LPS molecules and displaces calcium and magnesium ions. It solubilzes the cytoplasmic membrane resulting in leakage of cytosol which contributes to the bactericidal effect.

Mode of Action: Binds to lipids on the cell cytoplasmic membrane of Gram-negative bacteria and disrupts the cell wall integrity.
Antimicrobial spectrum: Gram-negative bacteria.

Other Notes

Keep container tightly closed in a dry and well-ventilated place.Keep in a dry place.

Molecular Weight: 1759.90. Empirical Formula: C₅₈H₁₁₅N₁₆Na₅O₂₈S₅. form: powder. Quality Level: 200. specific activity: ~11,500 . U/mg. solubility: H₂O: 50 . mg/mL. antibiotic activity spectrum: Gram-negative bacteria. Mode of action: cell membrane | interferes. storage temp.: 2-8°C. SMILES string: [Na+].[Na+].[Na+].[Na+].[Na+].CS([O-])(: O): O.CS([O-])(: O): O.CS([O-])(: O): O.CS([O-])(: O): O.CS([O-])(: O): O.CCC(C)CCCCC(: O)N[C@@H](CCN)C(: O)N[C@@H](C(C)O)C(: O)N[C@@H](CCN)C(: O)N[C@H]1CCNC(: O)[C@@H](NC(: O)[C@H](CCN)NC(: O)[C@@H](CCN)NC(: O)[C@H](CC(C)C)NC(: O)[C@@H](CC(C)C)NC(: O)[C@H](CCN)NC1: O)C(C)O. InChI: 1S/C53H100N16O13.5CH4O3S.5Na/c1-9-30(6)12-10-11-13-41(72)60-33(14-20-54)48(77)69-43(32(8)71)53(82)65-36(17-23-57)45(74)64-38-19-25-59-52(81)42(31(7)70)68-49(78)37(18-24-58)62-44(73)34(15-21-55)63-50(79)39(26-28(2)3)67-51(80)40(27-29(4)5)66-46(75)35(16-22-56)61-47(38)76. 5*1-5(2,3)4. . . . . /h28-40,42-43,70-71H,9-27,54-58H2,1-8H3,(H,59,81)(H,60,72)(H,61,76)(H,62,73)(H,63,79)(H,64,74)(H,65,82)(H,66,75)(H,67,80)(H,68,78)(H,69,77). 5*1H3,(H,2,3,4). . . . . /q. . . . . . 5*+1/p-5/t30?,31-,32-,33+,34-,35+,36+,37+,38+,39+,40-,42+,43+. . . . . . . . . . /m1........../s1. InChI key: WSDSONZFNWDYGZ-BKFDUBCBSA-I. Storage Class Code: 11 - Combustible Solids. WGK: WGK 3. Flash Point(F): Not applicable. Flash Point(C): Not applicable. Personal Protective Equipment: Eyeshields, Gloves, type N95 (US).