COENZYME A HYDRATE (C005B-082770)

Application

Coenzyme A hydrate has been used in the thiolase enzyme assay of recombinant acetoacetyl-CoA thiolase (rACAT) in Clonorchis sinensis. It may be used as a reference standard in Raman spectra measurements.

Biochem/physiol Actions

Coenzyme A (CoA) is an essential metabolic cofactor synthesized from cysteine, pantothenate, and ATP. CoA plays important roles in many metabolic pathways, including the tricarboxylic acid cycle, and the synthesis and oxidation of fatty acids. One of the main functions of CoA is the carrying and transfer of acyl groups. Acylated deriviates, for example acetyl-CoA, are critical intermediates in many metabolic reactions. CoA levels can be altered during starvation, and in conditions such as cancer, diabetes, and alcoholism.

Caution

The free acid is less stable than the sodium or lithium salt; 5% decomposition may occur within 6 months when stored at −20 °C.

Molecular Weight: 767.53 (anhydrous basis). Empirical Formula: C₂₁H₃₆N₇O₁₆P₃S · xH₂O. biological source: yeast. Quality Level: 200. Assay: ≥. 85% (UV, HPLC). form: powder. functional group: phospholipid. shipped in: ambient. storage temp.: −. 20°C. SMILES string: O.CC(C)(COP(O)(: O)OP(O)(: O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O): O)n2cnc3c(N)ncnc23)[C@@H](O)C(: O)NCCC(: O)NCCS. InChI: 1S/C21H36N7O16P3S.H2O/c1-21(2,16(31)19(32)24-4-3-12(29)23-5-6-48)8-41-47(38,39)44-46(36,37)40-7-11-15(43-45(33,34)35)14(30)20(42-11)28-10-27-13-17(22)25-9-26-18(13)28. /h9-11,14-16,20,30-31,48H,3-8H2,1-2H3,(H,23,29)(H,24,32)(H,36,37)(H,38,39)(H2,22,25,26)(H2,33,34,35). 1H2/t11-,14-,15-,16+,20-. /m1./s1. InChI key: TVSAELAFGDOPKI-BLPRJPCASA-N. Storage Class Code: 11 - Combustible Solids. WGK: WGK 3. Flash Point(F): Not applicable. Flash Point(C): Not applicable.