CNQX disodium salt (C007B-096191)

Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.application：CNQX disodium salt hydrate has been used as:as a competitive non-NMDA receptor antagonist and competitive AMPA/kainate receptor antagonist in neuronal cultures(110)as a glutamatergic blockers for measuring inhibitory postsynaptic currents in projection neurons(111)as a AMPA glutamate receptor antagonist prefrontal cortex neurons(112)参考 sigmaBiochemical mechanism:CNQX(6-cyano-7-nitroquinoxaline-2,3-dioneis) is a potent, competitive AMPA/kainate receptor antagonist. It is a quinoxaline derivative and also an antagonist for non-N-methyl-d-aspartate (non-NMDA) glutamate receptor. CNQX mediates depolarization thalamic reticular nucleus via α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptors (AMPARs). It displays micromolar affinity towards AMPA/kainate receptor.Potent, competitive AMPA/kainate receptor antagonist.

Specifications and Purity: ≥98%

Molecular Formula: C9H2N4Na2O4

Molecular Weight: 276.12

PubChem CID: 6093155

Isomeric SMILES: C1=C(C(=CC2=C1N=C(C(=N2)[O-])[O-])[N+](=O)[O-])C#N.[Na+].[Na+]

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