CITRIC ACID ANHYDROUS (C005B-080392)

Application

Citric acid was used as a test reagent for studying whether the novel pyridazinylpiperazine analog TPRV-1 inhibitor can reduce cough reflex induced by citric acid and capsaicin in guinea pig.

Biochem/physiol Actions

Citric acid in dietary form can augments absorption of aluminium in antacids. It also facilitates the phytoremediation of heavy metal contaminated soil and can transform cadmium into more transportable forms.

Molecular Weight: 192.12. Empirical Formula: C₆H₈O₇. linearFormula: HOC(COOH)(CH₂COOH)₂. Quality Level: 200. Assay: 99.5-100.5% (based on anhydrous substance). form: grit. quality: anhydrous, meets analytical specification of Ph. Eur., BP, USP, E330. expl. lim.: 8 . %, 65 . °F. impurities: residual solvents, complies, ≤. 0.0005% heavy metals (as Pb), ≤. 0.5% water (Karl Fischer). ign. residue: ≤. 0.05% (as SO₄). pKa : (1) 3.13, (2) 4.76, (3) 6.4. mp: 153-159 . °C (lit.). solubility: water: 383 . g/L at . 25 . °C. anion traces: chloride (Cl^-): ≤. 50 . ppm, oxalate (as oxalic acid): ≤. 100 . ppm, sulfate (SO₄^2-): ≤. 100 . ppm. cation traces: As: ≤. 1 . ppm, Ca: ≤. 200 . ppm, Cu: ≤. 10 . ppm, Fe: ≤. 10 . ppm, Hg: ≤. 1 . ppm, Pb: ≤. 0.5 . ppm, Zn: ≤. 10 . ppm. suitability: complies for appearance of solution, complies for reaction against H₂SO₄. SMILES string: OC(: O)CC(O)(CC(O): O)C(O): O. InChI: 1S/C6H8O7/c7-3(8)1-6(13,5(11)12)2-4(9)10/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12). InChI key: KRKNYBCHXYNGOX-UHFFFAOYSA-N. Gene Information: human ... SRC(6714).