Biochem/physiol Actions cis-22a is a potent and highly selective TrpV6 (CaT1, ECaC2) inhibitor (Cd2 + influx IC50 = 320 nM: hTRPV6 transfected HEK293) with much reduced and little potency against other calcium channels and related TRP targets.
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cis-22a is a potent and highly selective TrpV6 (CaT1, ECaC2) inhibitor (Cd2+ influx IC50 = 320 nM; hTRPV6 transfected HEK293) with much reduced and little potency against other calcium channels and related TRP targets. cis-22a selectively inhibits the growth of TrpV6-expressing breast cancer T47D (IC50 = 25 μM), but not TrpV6-negative ovarian carcinoma SKOV3 cultures (IC50 >50 μM).
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