General description
A cell-permeable selective inhibitor of cGMP-inhibited phosphodiesterase (PDE III; IC50 = 70 nM).
Biochem/physiol Actions
Cell permeable: yes
Primary Target
PDE 3
Product does not compete with ATP.
Reversible: no
Target IC50: 70 nM against PDE III
Warning
Toxicity: Standard Handling (A)
Reconstitution
Following reconstitution, refrigerate (4°C). Stock solutions are stable for up to 6 months at 4°C.
Other Notes
Verghese, M.W., et al. 1995. J. Pharmacol. Exp. Ther. 272, 1313.
Christensen, S.B., and Trophy, T.J. 1994. Ann. Rep. Med. Chem. 29, 185.
Tang, K.M., et al. 1994. Eur. J. Pharmacol. 268, 105.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Molecular Weight: 342.43. Empirical Formula: C20H26N2O3. Quality Level: 100. Assay: ≥. 98% (TLC). form: solid. manufacturer/tradename: Calbiochem®. . storage condition: OK to freeze. color: white. solubility: DMSO: 5 . mg/mL. shipped in: ambient. storage temp.: 2-8°C. InChI: 1S/C20H26N2O3/c1-22(16-6-3-2-4-7-16)20(24)8-5-13-25-17-10-11-18-15(14-17)9-12-19(23)21-18/h9-12,14,16H,2-8,13H2,1H3,(H,21,23). InChI key: UIAYVIIHMORPSJ-UHFFFAOYSA-N. Storage Class Code: 11 - Combustible Solids. WGK: WGK 3. Flash Point(F): Not applicable. Flash Point(C): Not applicable.- UPC:
- 12162205
- Condition:
- New
- HazmatClass:
- No
- MPN:
- 231085-10MG
- CAS:
- 68550-75-4
akash.verma@cenmed.com
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