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cilostamide

CILOSTAMIDE

Catalog No.
C005B-057205
Manufacturer No.
C7971-5MG
Manufacturer Name
Sigma-Aldrich
Quantity
5
Unit of Measure
MG

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Biochem/physiol Actions PDE3 catalyzes the phosphodiester bond hydrolysis, observed in secondory messengers such as cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP). Inhibitors of PDE3 are generally inotropic and

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Biochem/physiol Actions

PDE3 catalyzes the phosphodiester bond hydrolysis, observed in secondory messengers such as cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP). Inhibitors of PDE3 are generally inotropic and vasodilatory. They are being recognized for its use in treating heart failures. Cilostamide is known to delay meiotic progression.

Selective inhibitor of PDE3 (cGMP-inhibited phosphodiesterase); IC50 = 70 ± 9 nM. This inhibitory effect increases intracellular cAMP and inhibits platelet aggregation.

Molecular Weight: 342.43. Empirical Formula: C20H26N2O3. Quality Level: 100. Assay: ≥. 97% (HPLC). form: powder. solubility: DMSO: 20 . mg/mL, clear, colorless to faintly yellow. SMILES string: CN(C1CCCCC1)C(: O)CCCOc2ccc3NC(: O)C: Cc3c2. InChI: 1S/C20H26N2O3/c1-22(16-6-3-2-4-7-16)20(24)8-5-13-25-17-10-11-18-15(14-17)9-12-19(23)21-18/h9-12,14,16H,2-8,13H2,1H3,(H,21,23). InChI key: UIAYVIIHMORPSJ-UHFFFAOYSA-N. Gene Information: human ... PDE3A(5139), PDE3B(5140), PDE5A(8654), PDE7A(5150)
rat ... Pde2a(81743), Pde4a(25638). Storage Class Code: 11 - Combustible Solids. WGK: WGK 3. Flash Point(F): Not applicable. Flash Point(C): Not applicable. Personal Protective Equipment: Eyeshields, Gloves, type N95 (US).
UPC:
51171807
Condition:
New
HazmatClass:
No
MPN:
C7971-5MG
CAS:
68550-75-4

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