CI-1033 (C005B-029694)

Biochem/physiol Actions

CI-1033 is a potent, irreversible ATP binding site–directed pan-ErbB tyrosine kinase inhibitor with IC₅₀ in the low nanomolar range for EGFR, HER2, and ErbB-4.

Features and Benefits

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Molecular Weight: 558.86. Empirical Formula: C₂₄H₂₅ClFN₅O₃· 2HCl. Quality Level: 100. Assay: ≥. 98% (HPLC). form: solid. solubility: DMSO: >. 10 . mg/mL, H₂O: >. 10 . mg/mL. storage temp.: −. 20°C. SMILES string: Cl.Cl.Fc1ccc(Nc2ncnc3cc(OCCCN4CCOCC4)c(NC(: O)C: C)cc23)cc1Cl. InChI: 1S/C24H25ClFN5O3.2ClH/c1-2-23(32)30-21-13-17-20(14-22(21)34-9-3-6-31-7-10-33-11-8-31)27-15-28-24(17)29-16-4-5-19(26)18(25)12-16. . /h2,4-5,12-15H,1,3,6-11H2,(H,30,32)(H,27,28,29). 2*1H. InChI key: JZZFDCXSFTVOJY-UHFFFAOYSA-N. Gene Information: human ... EGFR(1956), ERBB2(2064), ERBB4(2066). Pictograms: GHS07. Signal Word: Warning. Hazard Statements: H315 - H319 - H335. Precautionary Statements: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338. Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3. Target Organs: Respiratory system. Storage Class Code: 11 - Combustible Solids. WGK: WGK 3. Flash Point(F): Not applicable. Flash Point(C): Not applicable.