CHOLECALCIFEROL MEETS USP TESTING SPECIFICATIONS (C005B-056883)

General description

Cholecalciferol (vitamin D3), a fat-soluble steroid is produced in the skin.

Application

Cholecalciferol has been used:

• to induce arterial medial calcification (AMC) in mice
• to study its impact in vascular remodeling associated with vascular calcification (VC) in murine model of obesity and insulin resistance (ob/ob mice)
• to study its effect on anchorage dependent growth of RWPE2-W99 cells in monolayer culture

Biochem/physiol Actions

Vitamin D acts through a receptor that is a member of the ligand-dependent transcription factor superfamily. Modulates the proliferation and differentiation of both normal and cancer cells. Has antiproliferative and antimetastatic effects on breast, colon, and prostate cancer cells. Activated vitamin D receptors in intestine and bone maintain calcium absorbance and homeostasis.

Molecular Weight: 384.64. Empirical Formula: C₂₇H₄₄O. Agency: USP/NF, meets USP testing specifications. Quality Level: 200. Assay: 97.0-103.0%. form: crystalline. color: white. mp: 83-86 . °C (lit.). application(s): pharmaceutical (small molecule). storage temp.: 2-8°C. SMILES string: CC(C)CCC[C@@H](C)[C@@]1([H])CC[C@@]([C@]1(C)CCC/2)([H])C2: C\C: C(C[C@@H](O)CC3)/C3: C. InChI: 1S/C27H44O/c1-19(2)8-6-9-21(4)25-15-16-26-22(10-7-17-27(25,26)5)12-13-23-18-24(28)14-11-20(23)3/h12-13,19,21,24-26,28H,3,6-11,14-18H2,1-2,4-5H3/b22-12+,23-13-/t21-,24+,25-,26+,27-/m1/s1. InChI key: QYSXJUFSXHHAJI-YRZJJWOYSA-N. Gene Information: human ... VDR(7421). Pictograms: GHS06,GHS08. Signal Word: Danger. Hazard Statements: H300 + H310 + H330 - H372. Precautionary Statements: P260 - P262 - P280 - P302 + P352 + P310 - P304 + P340 + P310 - P314. Hazard Classifications: Acute Tox. 2 Dermal - Acute Tox. 2 Inhalation - Acute Tox. 2 Oral - STOT RE 1 Oral. Storage Class Code: 6.1A - Combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials. WGK: WGK 2. Flash Point(F): Not applicable. Flash Point(C): Not applicable. Personal Protective Equipment: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges.