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chk2 inhibitor

Chk2 inhibitor (C007B-099361)

Catalog No.
C007B-099361
Manufacturer No.
C337162-500μg
Manufacturer Name
Aladdin Scientific
Quantity
1
Unit of Measure
EA

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Chk2 Inhibitor is an indoloazepine checkpoint kinase inhibitor that mediates apoptosis and cell cycle arrest. Checkpoint kinase 2 is activated upon DNA damage or genomic instability which eventually causes apoptosis. Mechanistic studies show that

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Chk2 Inhibitor is an indoloazepine checkpoint kinase inhibitor that mediates apoptosis and cell cycle arrest. Checkpoint kinase 2 is activated upon DNA damage or genomic instability which eventually causes apoptosis. Mechanistic studies show that Chk2 inhibitor causes autophosphorylation of Chk2 at Thr68 and targets ATP binding pockets of Chk2. Further studies demonstrate that Chk2 inhibitors also inhibit Chk1 and MEK-1 and affect interleukin-2 (IL-2), TNF-α, MEK-1, and GSK-3β.

Specifications and Purity: ≥95%

Molecular Formula: C15H13N5O2

Molecular Weight: 295.3

PubChem CID: 135433657

Isomeric SMILES: C1CNC(=O)C2=NC3=CC=CC=C3C2=C1C4=C(N=C(N4)N)O

Related Documents: https://aladdin-for-icloud-store.oss-cn-hangzhou.aliyuncs.com/aladdinsci/pdp/sds/1/C337162-SCI_529eb2278ec47ba87d6e6099b9c289e9.pdf

UPC:
51191805
Condition:
New
HazmatClass:
No
WeightUOM:
LB
MPN:
C337162-500μg
CAS:
724708-21-8
Product Size:
500μg
Precautionary Statement Codes:
P264

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