CGP 41251 (C007B-578598)

Midostaurin (PKC412) is a multi-targeted kinase inhibitor that acts on PKCα/β/γ, Syk, Flk-1, Akt, PKA, c-Kit, c-Fgr, c-Src, FLT3, PDFRβ, and VEGFR1/2, with an IC50 of 80-500 nM.Midostaurin ( pkc412) is a broad-spectrum protein kinase inhibitor. midostaurin (pkc412) strongly interacts with the ATP-binding sites of conventional PKC-α, -β and -γ, PDGFRβ, VEGF-R2, VEGF-R1, and the CDK 1-cyclin B complex. midostaurin (pkc412) was shown to interact with the ATP-binding sites of the CDK 1-cyclin B complex at similar sub-micromolar concentrations. midostaurin (pkc412) was found to be effective in the treatment of c-Fgr, c-Src, FLT3, PDFRβ, and VEGFR1/2. Midostaurin(pkc412) inhibited the growth of a variety of human and animal cell lines in vitro at similar submicromolar concentrations.Midostaurin(pkc412) also potently inhibited the proliferation of glioblastomas in vitro and induced the accumulation of cells in the G2/M phase and formation of megakaryotic nuclei with extensive fragmentation and apoptotic vesicles.Midostaurin(pkc412) was able to reverse the p-glycoprotein-mediated polymorphism of the tumor cells in vitro. p-glycoprotein-mediated multidrug resistance. [1]

Specifictaions: ≥99%

Specification: MFCD00871372

MDL Number: C35H30N4O4

Molecular Formula: 570.64

PubChem CID: 9829523

Isomeric SMILES: C[C@@]12[C@@H]([C@@H](C[C@@H](O1)N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N2C7=C53)CNC6=O)N(C)C(=O)C9=CC=CC=C9)OC