CCR7 Ligand 1 (C007B-343376)

CCR7 Ligand 1 (CCR7-Cmp2105) is an allosteric Ligand and antagonist for human CC chemokine receptor 7 (CCR7) with a K d of 3 nM. CCR7 Ligand 1, thiadiazole-dioxide ligan, suppresses arrestin binding in response to activation by CCL19 with an IC 50 of 7.3 μMIn VitroCCR7 Ligand 1 (CCR7-Cmp2105) binds to a pocket at the intracellular part of CCR7 between the ends of TM1, TM2, TM3, and TM6 and the loop between TM7 and H8. CCR7 Ligand 1 allosterically inhibits binding of the native chemokine CCL19 ligand in scintillation proximity assays (bottom) with an IC50 of 35 nM. CCR7 Ligand 1 (20, 40, 60, 80, 100 μM) has dose-dependent thermo-stabilizing effect on CCR7. MCE has not independently confirmed the accuracy of these methods. They are for reference only.Form:SolidIC50& Target:Human CCR7 3 nM (Kd).

Specifications and Purity: ≥99%

Molecular Formula: C22H29N5O5S

Molecular Weight: 475.56

PubChem CID: 136165388