General description
A potent and irreversible inhibitor of caspase-9 (ICE-LAP6, Mch6). Reported to reduce myocardial infarct size during reperfusion (~70 nM).
A potent, irreversible inhibitor of caspase-9. Reported to reduce myocardial infarct size during reperfusion (~70 nM).
Biochem/physiol Actions
Cell permeable: yes
Primary Target
caspase-9
Product does not compete with ATP.
Reversible: no
Target IC50: 70 nM against caspase-9
Warning
Toxicity: Standard Handling (A)
Sequence
Ac-Leu-Glu-His-Asp-CMK
Other Notes
Mocanu, M.M., et al. 2000. Br. J. Pharmacol.130, 197.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Molecular Weight: 587.02. Empirical Formula: C24H35ClN6O9. Quality Level: 100. Assay: ≥. 95% (HPLC). form: solid. manufacturer/tradename: Calbiochem®. . storage condition: OK to freeze, desiccated. color: white. solubility: water: 1 . mg/mL, DMSO: 5 . mg/mL. shipped in: ambient. storage temp.: −. 20°C. Storage Class Code: 11 - Combustible Solids. WGK: WGK 1. Flash Point(F): Not applicable. Flash Point(C): Not applicable.- UPC:
- 51182412
- Condition:
- New
- HazmatClass:
- No
- MPN:
- 218728-1MG
- CAS:
- 403848-57-7
akash.verma@cenmed.com
(732) 447-1115





