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carmofur (c15-1253-018)

CARMOFUR (C005B-052804)

Catalog No.
C005B-052804
Manufacturer No.
C1494-10MG
Manufacturer Name
Sigma-Aldrich
Quantity
10
Unit of Measure
MG

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Application Carmofur has been used as an inhibitor of acid ceramidase to study its effects on glucosylsphingosine (GlcSph) production in human embryonic kidney 293T (HEK293T) cells. It has also been used as an inhibitor of acid ceramidase to study

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Application

Carmofur has been used as an inhibitor of acid ceramidase to study its effects on glucosylsphingosine (GlcSph) production in human embryonic kidney 293T (HEK293T) cells. It has also been used as an inhibitor of acid ceramidase to study its effects on acid‐mediated hydrolysis of ceramide which kicks-in consumption and the generation of sphingosine .

Biochem/physiol Actions

Carmofur acts as an inhibitor of fatty acid amide hydrolase (FAAH), N-acylethanolamine acid amidase (NAAA) and acid ceramidase (ASAH1). Carmofur has a therapeutic activity against colorectal and cervical cancer. It can inhibit the severe acute respiratory syndrome (SARS)-CoV-2 main protease (Mpro) in vitro.

Carmofur is a derivative of fluorouracil, an antimetabolite used as an antineoplastic agent.

Molecular Weight: 257.26. Empirical Formula: C11H16FN3O3. Quality Level: 100. Assay: ≥. 98% (HPLC). form: powder. color: white to off-white. solubility: DMSO: >. 15 . mg/mL. storage temp.: 2-8°C. SMILES string: CCCCCCNC(: O)N1C: C(F)C(: O)NC1: O. InChI: 1S/C11H16FN3O3/c1-2-3-4-5-6-13-10(17)15-7-8(12)9(16)14-11(15)18/h7H,2-6H2,1H3,(H,13,17)(H,14,16,18). InChI key: AOCCBINRVIKJHY-UHFFFAOYSA-N. Pictograms: GHS06,GHS08. Signal Word: Danger. Hazard Statements: H301 - H361. Precautionary Statements: P201 - P301 + P310 + P330. Hazard Classifications: Acute Tox. 3 Oral - Repr. 2. Storage Class Code: 6.1A - Combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials. WGK: WGK 3. Flash Point(F): Not applicable. Flash Point(C): Not applicable.
UPC:
12352321
Condition:
New
HazmatClass:
Yes
MPN:
C1494-10MG
CAS:
61422-45-5

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