CARBENICILLIN READY MADE SOLUTION

General description

Chemical structure: ß-lactam

Application

Carbenicillin is used for selection of Ampicillin-resistant transformed cells. It is used to study the role of penicillin-sensitive transpeptidases in the process cell wall biosynthesis.

Biochem/physiol Actions

Carbenicillin is an ampicillin analog with structure related to benzyl penicillin. It is effective against Gram-negative bacteria and exhibits limited activity against Gram-positive bacteria. Carbenicillin binds and inhibits the enzymes involved in the synthesis of bacterial cell wall. Since carbenicillin is less sensitive to β-lactamases than ampicillin, it is effective against ampicillin-resistant bacteria. It has superior stability at low pH and acts as a selection agent. Effective concentration of carbenicillin: 50 to 100 μg/ml.

Other Notes

Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage.

Molecular Weight: 378.40. Empirical Formula: C₁₇H₁₈N₂O₆S. Quality Level: 200. sterility: 0.2 μ. m filtered. form: liquid. concentration: 100 . mg/mL in ethanol/water. solubility: H₂O: 100 . mg/mL, ethanol: 100 . mg/mL. suitability: suitable for testing specifications (Bacteriostatic (cell type) E. Coli DH5a, result: pass). antibiotic activity spectrum: Gram-negative bacteria, Gram-positive bacteria. Mode of action: cell wall synthesis | interferes. shipped in: wet ice. storage temp.: −. 20°C. SMILES string: CC1(C)S[C@@H]2[C@H](NC(: O)C(C(O): O)c3ccccc3)C(: O)N2[C@H]1C(O): O. InChI: 1S/C17H18N2O6S/c1-17(2)11(16(24)25)19-13(21)10(14(19)26-17)18-12(20)9(15(22)23)8-6-4-3-5-7-8/h3-7,9-11,14H,1-2H3,(H,18,20)(H,22,23)(H,24,25)/t9?,10-,11+,14-/m1/s1. InChI key: FPPNZSSZRUTDAP-UWFZAAFLSA-N. Pictograms: GHS02,GHS08. Signal Word: Danger. Hazard Statements: H226 - H317 - H334. Precautionary Statements: P210 - P233 - P240 - P241 - P280 - P303 + P361 + P353. Hazard Classifications: Flam. Liq. 3 - Resp. Sens. 1 - Skin Sens. 1. Storage Class Code: 3 - Flammable liquids. WGK: WGK 2. Flash Point(F): 104.0 °F - closed cup. Flash Point(C): 40 °C - closed cup. Personal Protective Equipment: Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter.