CARBAMAZEPINE (C005B-030116)

Application

Carbamazepine has been used to investigate its behavior in wastewater treatment and during groundwater infiltration. It has also been used to find out its effects on spontaneous seizures in rats.

Biochem/physiol Actions

Carbamazepine is considered as a safe antiepileptic drug. It decreases the multiple drug therapy and maintains a better control of epilepsy.

Anticonvulsant; ligand for the GABA_A receptor benzodiazepine modulatory site. Sodium channel inhibitor.

Features and Benefits

This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Molecular Weight: 236.27. Empirical Formula: C₁₅H₁₂N₂O. form: powder. Quality Level: 100. mp: 191-192 . °C (lit.). solubility: 45% (w/v) aq 2-hydroxypropyl-β. -cyclodextrin: 29 . mg/mL, H₂O: insoluble, ethanol: soluble, propylene glycol: soluble. originator: Novartis. storage temp.: 2-8°C. SMILES string: NC(: O)N1c2ccccc2C: Cc3ccccc13. InChI: 1S/C15H12N2O/c16-15(18)17-13-7-3-1-5-11(13)9-10-12-6-2-4-8-14(12)17/h1-10H,(H2,16,18). InChI key: FFGPTBGBLSHEPO-UHFFFAOYSA-N. Gene Information: human ... BZRAP1(9256), GABRA1(2554), GABRA2(2555), GABRA3(2556), GABRA4(2557), GABRA5(2558), GABRA6(2559), GABRB1(2560), GABRB2(2561), GABRB3(2562), PRNP(5621), SCN10A(6336), SCN11A(11280), SCN1A(6323), SCN2A(6326), SCN3A(6328), SCN4A(6329), SCN5A(6331), SCN7A(6332), SCN8A(6334), SCN9A(6335)
rat ... Scn2a1(24766), Scnn1a(25122), Scnn1g(24768), Slc6a1(79212). Pictograms: GHS07,GHS08. Signal Word: Danger. Hazard Statements: H302 - H317 - H334 - H336 - H360FD. Precautionary Statements: P202 - P261 - P280 - P301 + P312 - P302 + P352 - P308 + P313. Hazard Classifications: Acute Tox. 4 Oral - Repr. 1A - Resp. Sens. 1 - Skin Sens. 1A - STOT SE 3. Target Organs: Central nervous system. Storage Class Code: 6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects. WGK: WGK 2. Flash Point(F): Not applicable. Flash Point(C): Not applicable. Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Faceshields, Gloves.