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car, gst tagged, human

CAR GST TAGGED HUMAN

Catalog No.
C005B-306373
Manufacturer No.
SRP2146-10UG
Manufacturer Name
Sigma-Aldrich
Quantity
1
Unit of Measure
EA

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Biochem/physiol Actions The constitutive androstane receptor (CAR) was identified as a member of the orphan nuclear hormone receptor family in 1994. Although constitutively acitve, it can be further activated by ′:phenobarbitol-like′:

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Biochem/physiol Actions

The constitutive androstane receptor (CAR) was identified as a member of the orphan nuclear hormone receptor family in 1994. Although constitutively acitve, it can be further activated by ′phenobarbitol-like′ compounds, the most potent being the synthetic compound TCPOBOP. Upon activation, CAR regulates the xenobiotic drug metabolizing enzymes, cytochrome P450s. There are several overlapping functions between the nuclear receptors PXR and CAR. Recently, CAR, as well as PXR, have been shown to place a role in bile acid clearance and cholestatic liver injury.

Physical form

Clear and colorless frozen liquid solution

Preparation Note

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. While working, please keep sample on ice.

UPC:
42171607
Condition:
New
HazmatClass:
No
MPN:
SRP2146-10UG
Temperature Control Device:
Yes

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