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c4b-binding protein from human plasma

C4b-Binding Protein from Human Plasma

Catalog No.
C007B-590271
Manufacturer No.
np001118-1mg
Manufacturer Name
Aladdin Scientific
Quantity
1
Unit of Measure
EA

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Lyophilized from 10 mM Tris pH 7.4, 100 mM NaCl, 0.05% NaN3Free of Protein SC4b-binding protein is a regulatory protein of the Complement Cascade that possesses decay-accelerating activity. Circulating in plasma, it aids in the control of

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Lyophilized from 10 mM Tris pH 7.4, 100 mM NaCl, 0.05% NaN3Free of Protein SC4b-binding protein is a regulatory protein of the Complement Cascade that possesses decay-accelerating activity. Circulating in plasma, it aids in the control of fluid-phase and surface-associated activation of C3 and C5 and serves as a cofactor to Factor 1 in the proteolytic degradation of C4b.There are three isoforms circulating in plasma; 7 alpha chains and 1 Beta chain, 6 alpha chains and 1 Beta chain, and 7 alpha chains without a Beta chain. The 7 alpha, 1 Beta form is the most abundant. All C4BP molecules that contain a Beta chain circulate in plasma in a high-affinity, calcium-dependent complex with vitamin K-dependent, anticoagulant Protein S.C4b-binding protein has been investigated for its role in Alzheimer's Disease, Psoriasis, as well as autoimmune diseases including Rheumatoid Arthritis, and different types of Cancer.Product Citation:Sanderson-Smith, Martina, David MP De Oliveira, Julien Guglielmini, David J. McMillan, Therese Vu, Jessica K. Holien, Anna Henningham et al. "A systematic and functional classification of Streptococcus pyogenes that serves as a new tool for molecular typing and vaccine development."Journal of Infectious Diseases (2014): jiu260.Sanjay K. Singh et al.Functional transformation of C-reactive protein by hydrogen peroxide.J Biol Chem. 2017 Feb 24;292(8):3129-3136. doi: 10.1074/jbc.M116.773176. Epub 2017 Jan 17.

Specification: BioReagent, ≥95%(SDS-PAGE), Pre-lyophilization Protein Concentration

Related Documents: https://ald-pub-files.oss-cn-shanghai.aliyuncs.com/aladdinsci/pdp/sds/1/NP001118-SCI_b0ed2c2ab74fe8f0f59e2b36e6d6eefc.pdf

UPC:
12141723
Condition:
New
HazmatClass:
No
WeightUOM:
LB
MPN:
np001118-1mg
Product Size:
1mg

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