BTK ACTIVE HUMAN HIS TAGGED

Biochem/physiol Actions

BTK (also known as Bruton tyrosine kinase) plays a crucial role in B-lymphocyte differentiation and activation. BTK interacts with SRC homology 3 domains of FYN, LYN and HCK that are activated upon stimulation of B- and T-cell receptors.Defects in the BTK gene cause Agammaglobulinemia, an X-linked immunodeficiency characterized by failure to produce mature B lymphocyte cells and associated with a failure of Ig heavy chain rearrangement. The unique role of BTK makes it a desirable target for potential anti-cancer, anti-inflammatory and anti-viral agents as well as other treatments.

Physical form

Supplied in 50mM NaPhosphate pH 7.0, 300 mM NaCl, 150 mM imidazole, 0.1mM PMSF, 0.2 mM DTT, 25% glycerol.

Legal Information

PRECISIO is a registered trademark of Sigma-Aldrich Co. LLC

recombinant: expressed in baculovirus infected Sf9 cells. Quality Level: 100. product line: PRECISIO^®. Kinase. Assay: ≥. 70% (SDS-PAGE). form: buffered aqueous glycerol solution. specific activity: 37-49 . nmol/min·mg. mol wt: ~78 . kDa. UniProt accession no.: Q06187. shipped in: dry ice. storage temp.: −. 70°C. Gene Information: human ... BTK(695). Pictograms: GHS07,GHS08. Signal Word: Danger. Hazard Statements: H315 - H319 - H360D. Precautionary Statements: P202 - P264 - P280 - P302 + P352 - P305 + P351 + P338 - P308 + P313. Hazard Classifications: Eye Irrit. 2 - Repr. 1B - Skin Irrit. 2. Storage Class Code: 6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects. WGK: WGK 1. Flash Point(F): Not applicable. Flash Point(C): Not applicable. Personal Protective Equipment: Eyeshields, Faceshields, Gloves, multi-purpose combination respirator cartridge (US).