BRETAZENIL >=96% (HPLC) SOLID (C005B-082367)

General description

Bretazenil, a tetracyclic imidazocarboxylic ester, is an anxi-olytic/anticonvulsant agent. It possesses a half-life of 2.5 hours and is quickly absorbed.

Application

Bretazenil has been used to determine non-specific binding due to its affinity to bind to a variety of γ-aminobutyric acid type A (GABAA) receptor subtypes (α1-3;5). It has also been used as a GABAA receptor partial agonist in the subcutaneous Alzet minipumps to treat obese agouti?related protein (AgRP)?ablated and lean naive mice to study its effect on them.

Biochem/physiol Actions

Bretazenil is capable of binding to γ-aminobutyric acid type A (GABAA) receptors that are sensitive and insensitive to diazepam. This compound possesses negligible sedative or muscle relaxant effects.

Bretazenil is a benzodiazepine partial agonist.

Features and Benefits

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This compound was developed by Roche. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Molecular Weight: 418.28. Empirical Formula: C₁₉H₂₀N₃O₃Br. Quality Level: 100. Assay: ≥. 96% (HPLC). form: solid. color: white. solubility: DMSO: 24 . mg/mL, H₂O: insoluble. originator: Roche. storage temp.: 2-8°C. SMILES string: [H][C@@]12CCCN1C(: O)c3c(Br)cccc3-n4cnc(C(: O)OC(C)(C)C)c24. InChI: 1S/C19H20BrN3O3/c1-19(2,3)26-18(25)15-16-13-8-5-9-22(13)17(24)14-11(20)6-4-7-12(14)23(16)10-21-15/h4,6-7,10,13H,5,8-9H2,1-3H3/t13-/m0/s1. InChI key: LWUDDYHYYNNIQI-ZDUSSCGKSA-N. Storage Class Code: 11 - Combustible Solids. WGK: WGK 3. Flash Point(F): Not applicable. Flash Point(C): Not applicable. Personal Protective Equipment: Eyeshields, Gloves, type N95 (US).