BRADYKININ FRAGMENT 1-7

Amino Acid Sequence

Arg-Pro-Pro-Gly-Phe-Ser-Pro

General description

Bradykinin fragment 1-7 (BK-(1-7)), an endogenous peptide, is present in plasma.

Application

Bradykinin Fragment 1-7 has been used as an external calibrant/standard in the matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS) analysis of protein spots.

Bradykinin Fragment 1-7 is used in research on the specificity and kinetics of kininase(s).

Biochem/physiol Actions

Bradykinin (BK) is a pro-inflammatory mediator and a neuromediator. It modulates several vascular and renal functions. Bradykinin (BK) plays a key role in inducing vascular permeability and mitogenesis. It helps to activate the liberation of nitric oxide in inflammatory and cancer tissues.

Molecular Weight: 756.85. Empirical Formula: C₃₅H₅₂N₁₀O₉. Quality Level: 200. Assay: ≥. 97% (HPLC). form: powder. color: white. UniProt accession no.: P01161. storage temp.: −. 20°C. SMILES string: NC(CCCNC(N): N)C(: O)N1CCCC1C(: O)N2CCCC2C(: O)NCC(: O)NC(Cc3ccccc3)C(: O)NC(CO)C(: O)N4CCCC4C(O): O. InChI: 1S/C35H52N10O9/c36-22(10-4-14-39-35(37)38)31(50)44-16-6-12-26(44)33(52)43-15-5-11-25(43)30(49)40-19-28(47)41-23(18-21-8-2-1-3-9-21)29(48)42-24(20-46)32(51)45-17-7-13-27(45)34(53)54/h1-3,8-9,22-27,46H,4-7,10-20,36H2,(H,40,49)(H,41,47)(H,42,48)(H,53,54)(H4,37,38,39). InChI key: CRROPKNGCGVIOG-UHFFFAOYSA-N. Gene Information: rat ... Nppa(24602). Storage Class Code: 11 - Combustible Solids. WGK: WGK 3. Flash Point(F): Not applicable. Flash Point(C): Not applicable. Personal Protective Equipment: Eyeshields, Gloves, type N95 (US).