BPK-29 (C005B-310880)

Catalog No.: C005B-310880
Manufacturer No.: SML2305-5MG
Manufacturer Name: Sigma-Aldrich
Quantity: 5
Unit of Measure: MG

Biochem/physiol Actions BPK-29 is a potent and selective NR0B1 ligand that covalently binds to NR0B1 Cys 274. BPK-29 inhibits the NR0B1-SNW1 interaction.

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Description
Specifications

Biochem/physiol Actions

BPK-29 is a potent and selective NR0B1 ligand that covalently binds to NR0B1 Cys 274. BPK-29 inhibits the NR0B1-SNW1 interaction. It inhibits the anchorage-independent growth of KEAP1-mutant cancer cells.

BPK-29 is a small molecule inhibitor that blocks the nuclear factor erythroid 2â€“related factor 2 (NRF2) pathway. It targets the cysteine 274 residue in the nuclear receptor subfamily 0 group B member 1 (NR0B1) and disrupts protein-protein interactions in non-small-cell lung cancer (NSCLC) cell proteomes.

UPC:: 12141723
Condition:: New
HazmatClass:: No
MPN:: SML2305-5MG
CAS:: 2143467-62-1

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