BORON TRIBROMIDE 1.0M SOLUTION IN DICHLOROMETHANE (C005B-004689)

General description

Boron tribromide (BBr₃) is a commonly used reagent in organic chemistry for demethylation.

Application

Reactant for preparation of:

• Drug intermediate 6-nitro-L-DOPA
• Luminescent polystyrene derivatives with sterically protected carbazolylborane moieties
• High-quality boron-doped graphene via Wurtz-type reductive coupling reaction
• Mercapto-(+)-methamphetamine haptens for synthesis of (+)-methamphetamine conjugate vaccines with improved epitope densities
• Micrometer-sized organic molecule-DNA hybrid structures
• Borane complexes via electrophilic aromatic borylation reactions
• A 5-HT2C receptor agonist
• Biphenyl-derivatives possessing tertiary amino groups as ß-secretase(BACE1) inhibitors for the treatment of Alzheimer′s disease
• A highly near-IR region fluorescent p-extended boron aza-dipyrromethene moiety unit
• Tetrahydroisoquinoline derivatives via intramolecular cyclization of methoxy-substituted N-phenethylimides

Used to cleave aryl methyl ethers in a synthesis of a benzopyranobenzopyran from a coumarin scaffold.

Packaging

The 25 mL Sure/Seal^™ bottle is recommended as a single-use bottle. Repeated punctures will likely result in decreased performance of product.

Legal Information

Sure/Seal is a trademark of Sigma-Aldrich Co. LLC

Molecular Weight: 250.52. Empirical Formula: BBr₃. form: liquid. Quality Level: 200. concentration: 1.0 . M in methylene chloride. density: 1.467 . g/mL . at 25 . °C. SMILES string: BrB(Br)Br. InChI: 1S/BBr3/c2-1(3)4. InChI key: ILAHWRKJUDSMFH-UHFFFAOYSA-N. Pictograms: GHS05,GHS06,GHS08. Signal Word: Danger. Hazard Statements: H300 + H330 - H314 - H336 - H351. Precautionary Statements: P202 - P260 - P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338. Hazard Classifications: Acute Tox. 2 Inhalation - Acute Tox. 2 Oral - Carc. 2 - Eye Dam. 1 - Skin Corr. 1A - STOT SE 3. Target Organs: Central nervous system. Storage Class Code: 6.1A - Combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials. WGK: WGK 3. Flash Point(F): Not applicable. Flash Point(C): Not applicable. Personal Protective Equipment: Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter.