BORANE-TETRAHYDROFURAN COMPLEX 1.0M SOLUTION IN TETRAHYDROFURAN (C005B-017166)

General description

Borane tetrahydrofuran complex (BH₃-THF) is widely used as a reducing agent in organic synthesis. It is also used as a reagent in hydroboration reactions.

Application

New, Safer, NIMBA-Stabilized BH3 THF Solutions

BH₃-THF can be used as a reducing agent for the reduction of various functional groups such as carboxylic acids, aldehydes, ketones, esters, acid chlorides, nitriles, epoxides, amides, lactones, oximes, and imines into corresponding alcohols and amines. Grignard reagents, arylmercury, arylthalium, and allyl and propargyllithium compounds react with BH₃−THF to give organoboranes, which can be oxidized to the corresponding alcohols, phenols, and 1,3-diols.
It can also be used:

• To synthesize the chiral borane catalyst, which is used in the enantioselective halo-aldol reaction.
• To prepare 9-unsubstituted acridines by reduction of corresponding acridones.
• To reduce nylon surface amide groups to secondary amines.

Packaging

The 25 mL Sure/Seal^™ bottle is recommended as a single-use bottle. Repeated punctures will likely result in decreased performance of product.

Legal Information

Sure/Seal is a trademark of Sigma-Aldrich Co. LLC

Molecular Weight: 85.94. Empirical Formula: C₄H₁₁BO. linearFormula: BH₃OC₄H₈. contains: <. 0.005 . M sodium borohydride as stabilizer. Quality Level: 200. reaction suitability: reagent type: reductant. concentration: 1.0 . M in THF. density: 0.898 . g/mL . at 25 . °C. storage temp.: 2-8°C. SMILES string: B.C1CCOC1. InChI: 1S/C4H8O.BH3/c1-2-4-5-3-1. /h1-4H2. 1H3. InChI key: RMCYTHFAWCWRFA-UHFFFAOYSA-N. Pictograms: GHS02,GHS05,GHS07,GHS08. Signal Word: Danger. Hazard Statements: H225 - H260 - H302 - H318 - H335 - H336 - H351. Precautionary Statements: P210 - P231 + P232 - P280 - P301 + P312 - P305 + P351 + P338 - P308 + P313. Hazard Classifications: Acute Tox. 4 Oral - Carc. 2 - Eye Dam. 1 - Flam. Liq. 2 - Water-react 1. Supp Hazards: EUH019. Storage Class Code: 4.3 - Hazardous materials, which set free flammable gases upon contact with water. WGK: WGK 2. Flash Point(F): 1.4 °F - closed cup. Flash Point(C): -17 °C - closed cup.