BMS-1001 (C007B-068273)

InformationBMS-1001 BMS-1001 is a potent inhibitor of PD-1/PD-L1 interaction with EC50 of 253 nM. BMS-1001 alleviates the inhibitory effect of the soluble PD-L1 on the T-cell receptor-mediated activation of T-lymphocytes.TargetsPD-1/PD-L1 (Cell-free assay) 253 nM(EC50)In vitroBMS-1001 alleviates the inhibitory effect of the soluble PD-L1 on the T-cell receptor-mediated activation of T-lymphocytes. BMS-1001 is effective in attenuating the inhibitory effect of the cell surface-associated PD-L1.Cell Research(from reference)Cell lines：PD-L1+ aAPC/CHO-K1 cells (aAPCs), PD-1 Effector Cells (ECs) Concentrations：0.12 μM, 0.3 μM, 1.2 μM, 3 μM Incubation Time：24 h.

Specifications and Purity: ≥98%

Molecular Formula: C35H34N2O7

Molecular Weight: 594.65

PubChem CID: 131839624

Isomeric SMILES: CC1=CC(=C(C=C1OCC2=C(C(=CC=C2)C3=CC4=C(C=C3)OCCO4)C)OCC5=CC(=CC=C5)C#N)CN[C@H](CO)C(=O)O