BISOPROLOL HEMIFUMARATE (C005B-005269)

Application

Bisoprolol hemifumarate salt has been used as a β-adrenergic receptor (β-AR) antagonist in cardiac fibrosis mice model.

Biochem/physiol Actions

Bisoprolol hemifumarate is useful in oral formulations due to its high bioavailability. It also shows long elimination half-life.

Cardioselective β₁-adrenoceptor antagonist.

Features and Benefits

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This compound was developed by Teva. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Molecular Weight: 383.48. Empirical Formula: C₁₈H₃₁NO₄ · .5C₄H₄O₄. Quality Level: 100. Assay: ≥. 98% (HPLC). form: solid. color: white. solubility: DMSO: >. 20 . mg/mL. originator: Teva. SMILES string: OC(: O)\C: C\C(O): O.CC(C)NCC(O)COc1ccc(COCCOC(C)C)cc1.CC(C)NCC(O)COc2ccc(COCCOC(C)C)cc2. InChI: 1S/2C18H31NO4.C4H4O4/c2*1-14(2)19-11-17(20)13-23-18-7-5-16(6-8-18)12-21-9-10-22-15(3)4. 5-3(6)1-2-4(7)8/h2*5-8,14-15,17,19-20H,9-13H2,1-4H3. 1-2H,(H,5,6)(H,7,8)/b. . 2-1+. InChI key: VMDFASMUILANOL-WXXKFALUSA-N. Gene Information: human ... ADRB1(153). Pictograms: GHS07,GHS08. Signal Word: Warning. Hazard Statements: H302 - H361fd - H373. Precautionary Statements: P202 - P260 - P264 - P280 - P301 + P312 - P308 + P313. Hazard Classifications: Acute Tox. 4 Oral - Repr. 2 - STOT RE 2. Target Organs: Heart. Storage Class Code: 11 - Combustible Solids. WGK: WGK 3. Flash Point(F): Not applicable. Flash Point(C): Not applicable. Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves.