BISANTRENE DIHYDROCHLORIDE (C005B-080531)

Application

Bisantrene (NSC 337766), and its derivatives are topoisomerase II poisons and DNA intercalators. It may be used as model compounds to study P-glycoprotein-mediated multiple drug resistance (MDR1). Bisantrene may be used as a Rac1 inhibitor.

Biochem/physiol Actions

Bisantrene dihydrochloride is an antineoplastic agent, MDR1 substrate, DNA intercalator, and topoisomerase II poison. Cancer cells that develop resistance to bisantrene tend to overexpress P-glycoprotein. Bisantrene can be used to select for P-glycoprotein-mediated multiple drug resistance. The data suggest that bisantrene is an excellent substrate for P-glycoprotein.

Bisantrene is an anthracene bishydrazone derivative, which has antitumor activity.

Molecular Weight: 471.39. Empirical Formula: C₂₂H₂₂N₈ ·2HCl. Quality Level: 100. Assay: ≥. 98% (HPLC). form: solid. storage condition: desiccated. solubility: deionized water: 8 . mg/mL. storage temp.: room temp. SMILES string: Cl.Cl.C1CN: C(N1)N\N: C\c2c3ccccc3c(\C: N\NC4: NCCN4)c5ccccc25. InChI: 1S/C22H22N8.2ClH/c1-2-6-16-15(5-1)19(13-27-29-21-23-9-10-24-21)17-7-3-4-8-18(17)20(16)14-28-30-22-25-11-12-26-22. . /h1-8,13-14H,9-12H2,(H2,23,24,29)(H2,25,26,30). 2*1H/b27-13+,28-14+. . . InChI key: KINULKKPVJYRON-PVNXHVEDSA-N. Pictograms: GHS07,GHS09. Signal Word: Warning. Hazard Statements: H302 - H400. Precautionary Statements: P273 - P301 + P312 + P330. Hazard Classifications: Acute Tox. 4 Oral - Aquatic Acute 1. Storage Class Code: 6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects. WGK: WGK 3. Flash Point(F): Not applicable. Flash Point(C): Not applicable.