BINDARIT (C005B-309895)

Catalog No.: C005B-309895
Manufacturer No.: SML2910-25MG
Manufacturer Name: Sigma-Aldrich
Quantity: 25
Unit of Measure: MG

Biochem/physiol Actions Bindarit is an indazolic derivative with anti-inflammatory efficacy in vitro (150-300 μ:M) and in animal disease models in vivo (100 mg/kg ip, 50 mg/kg po, or 0.5% in chow: rats &: mice).

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Description
Specifications

Biochem/physiol Actions

Bindarit is an indazolic derivative with anti-inflammatory efficacy in vitro (150-300 μM) and in animal disease models in vivo (100 mg/kg ip, 50 mg/kg po, or 0.5% in chow; rats & mice). Bindarit selectively inhibits LPS-induced CCL2/MCP-1, CCL7/MCP-3, CCL8/MCP-2 chemokines over CCL3/MIP-1α and IL-8/CXCL8 in human monocytes, while blocking CCL2, but not CCL7 or CCL8, induction in HUVECs, and preventing LPS-induced CCL2 & IL-12β/p40 by inhibiting NFκB activation in murine macrophages (BMDM & Raw 264.7). Bindarit is also reported to exhibit non-competitive inhibiory potency against human monocarboxylate transporter MCT4 (K_i = 30.2 μM) over MCT1 (<40% inhibition at 500 μM).

UPC:: 42312501
Condition:: New
HazmatClass:: No
MPN:: SML2910-25MG
CAS:: 130641-38-2

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