BETA-ESTRADIOL 3-SULFATE SODIUM SALT >=93%

General description

β-Estradiol is secreted by developing ovaries and is predominant during premenopause in women.

Application

β-Estradiol 3-sulfate sodium salt has been used to measure the estradiol level from culture supernatant in ultra-performance liquid chromatography-tandem mass spectrometry.

Biochem/physiol Actions

β-Estradiol is a steroid hormone involved in a number of organ functions. It is significantly associated with brain functions including neuroprotection, neurogenesis and synaptic plasticity. β-Estradiol maintains bone homeostasis, hence it is preferred for osteoporosis therapy. 17-β-Estradiol is the most active estrogen generated in our body. During postmenopausal, 17-β-estradiol inhibits oxidative modification in low density lipoprotein. This indicates that estrogen replacement therapy might be useful in treating cardiovascular disease.

Packaging

Package size based on steroid content

Molecular Weight: 374.43. Empirical Formula: C₁₈H₂₃NaO₅S. linearFormula: C₁₈H₂₃O₅SNa. sterility: non-sterile. Quality Level: 200. Assay: ≥. 93%. form: powder. contains: ~70% N-methyl-D-glucamine as stabilizer. solubility: methanol: 9.80-10.20 . mg/mL, clear, colorless to faintly yellow. shipped in: ambient. storage temp.: room temp. SMILES string: [Na].[H][C@]12CC[C@]3(C)[C@@H](O)CC[C@@]3([H])[C@]1([H])CCc4cc(OS(O)(: O): O)ccc24. InChI: 1S/C18H24O5S.Na.H/c1-18-9-8-14-13-5-3-12(23-24(20,21)22)10-11(13)2-4-15(14)16(18)6-7-17(18)19. . /h3,5,10,14-17,19H,2,4,6-9H2,1H3,(H,20,21,22). . /t14-,15-,16+,17+,18+. . /m1../s1. InChI key: PYPVMTJYMKHIST-LBARCDFESA-N. Pictograms: GHS07,GHS08. Signal Word: Warning. Hazard Statements: H302 + H332 - H351. Precautionary Statements: P202 - P261 - P264 - P301 + P312 - P304 + P340 + P312 - P308 + P313. Hazard Classifications: Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Carc. 2. Storage Class Code: 11 - Combustible Solids. WGK: WGK 3. Flash Point(F): Not applicable. Flash Point(C): Not applicable. Personal Protective Equipment: Eyeshields, Gloves, type P3 (EN 143) respirator cartridges.