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beta-estradiol 17-valerate

B-ESTRADIOL 17-VALERATE

Catalog No.
C005B-092064
Manufacturer No.
E1631-1G
Manufacturer Name
Sigma-Aldrich
Quantity
1
Unit of Measure
GR

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β-Estradiol 17-valerate is a synthetic estrogen. Application β-Estradiol 17-valerate has been used: in an in-vivo assay, to synchronize the estrus cycle in athymic nude mice, to study the effect of recombinant pigment epithelium-derived

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General description

β-Estradiol 17-valerate is a synthetic estrogen.

Application

β-Estradiol 17-valerate has been used:

  • in an in-vivo assay, to synchronize the estrus cycle in athymic nude mice, to study the effect of recombinant pigment epithelium-derived factor (rPEDF) on induced ectopic fibroid lesions
  • to study the influence of ovarian hormones on type II cGMP-dependent protein kinase (Prkg2) expression in mice
  • to induce growth of estrogen-dependent tumor cells in athymic nude mice to establish a breast cancer mouse model

Biochem/physiol Actions

Estradiol valerate is observed to be useful for treating menopausal climacteric symptoms. β-Estradiol 17-valerate is used as a source of 17β-estradiol (E2) in in vitro fertilization, hormone replacement therapy, contraceptive drugs, to study reproductive disorders in animal models. It serves as growth promoter in animal farming. β-Estradiol 17-valerate is also used to culture single-sex population among fish. Studies in rats show that β-Estradiol 17-valerate has negative effects on the estrus cycle pattern.

Molecular Weight: 356.50. Empirical Formula: C23H32O3. biological source: synthetic. Quality Level: 100. Assay: ≥. 98%. form: powder. technique(s): ELISA: suitable. solubility: acetone: 25 . mg/mL, hazy, colorless. shipped in: ambient. storage temp.: room temp. SMILES string: CCCCC(: O)OC1CCC2C3CCc4cc(O)ccc4C3CCC12C. InChI: 1S/C23H32O3/c1-3-4-5-22(25)26-21-11-10-20-19-8-6-15-14-16(24)7-9-17(15)18(19)12-13-23(20,21)2/h7,9,14,18-21,24H,3-6,8,10-13H2,1-2H3. InChI key: RSEPBGGWRJCQGY-UHFFFAOYSA-N. Pictograms: GHS08,GHS09. Signal Word: Warning. Hazard Statements: H351 - H361fd - H362 - H410. Precautionary Statements: P201 - P202 - P260 - P263 - P273 - P308 + P313. Hazard Classifications: Aquatic Chronic 1 - Carc. 2 - Lact. - Repr. 2. Storage Class Code: 6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects. WGK: WGK 3. Personal Protective Equipment: Eyeshields, Gloves, type P3 (EN 143) respirator cartridges.
UPC:
12142204
Condition:
New
HazmatClass:
No
MPN:
E1631-1G
CAS:
979-32-8

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