BERBERINE CHLORIDE (C005B-054397)

General description

Berberine Chloride form or Natural Yellow 18, is also known as 5,6-dihydro-9,10-dimethoxybenzo(g)-1,3-benzodioxolo (5,6-a) quinolizinium is a benzyl tetra isoquinoline plant alkaloid. Berberine contains a quaternary base and is commercially available in berberine chloride form.

Application

Berberine Chloride is a fluorescent stain used to stain heparin in mast cells. Berberine upregulates the expression of Pgp in hepatoma cells.

Fluorescent stain for heparin in mast cells

Biochem/physiol Actions

An alkaloid with weak antibiotic properties. Substrate for MDR efflux pumps. Antimicrobial activities of berberine is potentiated by the MDR inhibitor 5´-methoxyhydnocarpin (5´-MHC). Berberine upregulates the expression of Pgp in hepatoma cells. Treatment with berberine potentially results in the reduced accumulation of chemotherapeutic drugs.

Molecular Weight: 371.81. Empirical Formula: C₂₀H₁₈ClNO₄. form: powder. Quality Level: 200. solubility: methanol: soluble. SMILES string: COC1: C(C: [N+](CCC2: C3C: C4C(OCO4): C2)C3: C5)C5: CC: C1OC.[Cl-]. InChI: 1S/C20H18NO4.ClH/c1-22-17-4-3-12-7-16-14-9-19-18(24-11-25-19)8-13(14)5-6-21(16)10-15(12)20(17)23-2. /h3-4,7-10H,5-6,11H2,1-2H3. 1H/q+1. /p-1. InChI key: VKJGBAJNNALVAV-UHFFFAOYSA-M. Storage Class Code: 11 - Combustible Solids. WGK: WGK 2. Flash Point(F): Not applicable. Flash Point(C): Not applicable. Personal Protective Equipment: Eyeshields, Gloves, type N95 (US).