BENZO(A)PYRENE (C005B-045016)

Application

Benzo[a]pyrene (PAH), a polycyclic aromatic hydrocarbon pollutant, is used as a chemical carcinogen in experimental models of cancer. Carcinogenesis depends on it′s oxidation by CYP1A1 to benzo[a]pyrenediolepoxide, that forms depurinating adducts with DNA that dissociate to form abasic lesions. Benzo[a]pyrene is a ligand for the arylhydrocarbon receptor (AhR), and some of its biological effects, including the induction of CYP1A1, appear to be mediated via activation of the AhR.

Molecular Weight: 252.31. Empirical Formula: C₂₀H₁₂. Quality Level: 200. Assay: ≥. 96% (HPLC). form: solid. bp: 495 . °C (lit.). mp: 177-180 . °C (lit.). SMILES string: c1ccc2c(c1)cc3ccc4cccc5ccc2c3c45. InChI: 1S/C20H12/c1-2-7-17-15(4-1)12-16-9-8-13-5-3-6-14-10-11-18(17)20(16)19(13)14/h1-12H. InChI key: FMMWHPNWAFZXNH-UHFFFAOYSA-N. Pictograms: GHS07,GHS08,GHS09. Signal Word: Danger. Hazard Statements: H317 - H340 - H350 - H360FD - H410. Precautionary Statements: P202 - P261 - P273 - P280 - P302 + P352 - P308 + P313. Hazard Classifications: Aquatic Acute 1 - Aquatic Chronic 1 - Carc. 1B - Muta. 1B - Repr. 1B - Skin Sens. 1. Storage Class Code: 6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects. WGK: WGK 3. Flash Point(F): Not applicable. Flash Point(C): Not applicable.