BENSERAZIDE HYDROCHLORIDE (C005B-019096)

General description

Benserazide is a peripheral decarboxylase inhibitor.

Application

Benserazide has been used:

• to inhibit dopa-decarboxylase
• to induce dyskinesia
• to test on purified bacterial TDCs to assess the extent to which it could affect bacterial decarboxylases
• as a peripheral dopa decarboxylase inhibitor to treat mice

Biochem/physiol Actions

Benserazide can block HK2 enzymatic activity in vitro. It is used along with levodopa to treat Parkinson′s disease.

Inhibitor of L-aromatic amino acid decarboxylase.

Features and Benefits

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound was developed by Roche. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Molecular Weight: 293.70. Empirical Formula: C₁₀H₁₅N₃O₅ · HCl. biological source: synthetic. Quality Level: 100. Assay: ≥. 98% (HPLC). form: solid. solubility: H₂O: 10 . mg/mL. originator: Roche. storage temp.: room temp. SMILES string: Cl.NC(CO)C(: O)NNCc1ccc(O)c(O)c1O. InChI: 1S/C10H15N3O5.ClH/c11-6(4-14)10(18)13-12-3-5-1-2-7(15)9(17)8(5)16. /h1-2,6,12,14-17H,3-4,11H2,(H,13,18). 1H. InChI key: ULFCBIUXQQYDEI-UHFFFAOYSA-N. Gene Information: human ... DDC(1644). Pictograms: GHS07. Signal Word: Warning. Hazard Statements: H315 - H319 - H335. Precautionary Statements: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338. Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3. Target Organs: Respiratory system. Storage Class Code: 11 - Combustible Solids. WGK: WGK 2. Flash Point(F): Not applicable. Flash Point(C): Not applicable. Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves.