(+/-)-BAY K8644 (C005B-058399)

Application

(±)-Bay K8644 has been used as an agonist for voltage sensitive calcium channels (VSCCs) in interneurons, L-type calcium channel (LTCC) in human embryonic kidney 293 cells and viscerofugal neurons.

Biochem/physiol Actions

(±)-Bay K8644 is a 1,4-dihydropyridine (DHP) derivative and an agonist for L-type Ca²⁺ channels. However, it′s enantiomers (-)-BAY k8644 and (+)-BAY k8644 have opposing functionality with respect to Ca2+ channels as high-potency agonist and low-potency antagonist, respectively. (±)-Bay K8644 increases influx of Ca²⁺ specifically at voltage-gated calcium channels. It constricts blood vessels and heart contraction.

Increases influx of Ca²⁺ specifically at voltage-gated calcium channels.

Molecular Weight: 356.30. Empirical Formula: C₁₆H₁₅F₃N₂O₄. Quality Level: 100. Assay: ≥. 97.5% (HPLC). form: powder. color: yellow to dark yellow. mp: 168-170  . °C. solubility: DMSO: 20 . mg/mL, methanol and ethanol: 63 . mg/mL, H₂O: insoluble. storage temp.: 2-8°C. SMILES string: CC1: C(C(OC): O)C(C2: CC: CC: C2C(F)(F)F)C([N+]([O-]): O): C(C)N1. InChI: 1S/C16H15F3N2O4/c1-8-12(15(22)25-3)13(14(21(23)24)9(2)20-8)10-6-4-5-7-11(10)16(17,18)19/h4-7,13,20H,1-3H3. InChI key: ZFLWDHHVRRZMEI-UHFFFAOYSA-N. Gene Information: rat ... Cacna1c(24239). Pictograms: GHS07. Signal Word: Warning. Hazard Statements: H315 - H319. Precautionary Statements: P264 - P280 - P302 + P352 - P305 + P351 + P338 - P332 + P313 - P337 + P313. Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2. Storage Class Code: 11 - Combustible Solids. WGK: WGK 3. Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves.