BAY-899 (C007B-336713)

BAY-899 is an orally active and selective luteinizing hormone receptor (LH-R) antagonist with IC 50 s of 185 nM and 46nM for hLH (human LH) and rLH (rat LH), respectively. BAY-899 can reduce sex hormone levelsIn VivoBAY-899 (oral; 12.5 mg/kg/day; for 8 days) shows an efficiency to reduce serum estradiol levels in intact female rats . BAY-899 (iv of 0.5 mg/kg or po of 2 mg/kg) has a t 1/2 of 11 hours and 12 hours for iv and po. And the C max is 0.97 kg/L and 0.24 kg/L for iv and po . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Intact female rats Dosage: 12.5 mg/kg Administration: Oral; for 8 days Result: Showed an efficiency to reduce serum estradiol levels. Animal Model: Female and male Wistar rats Dosage: 0.5 mg/kg of iv or 2 mg/kg of po Administration: Iv or po Result: Has t 1/2 s of 11 hours and 12 hours for iv and po. And the C max s are 0.97 kg/L and 0.24 kg/L for iv and po.IC50& Target:IC50: 185 nM (hLH) and 46nM (rLH).

Specifications and Purity: 10mM in DMSO

Molecular Formula: C25H19F2N5O2

Molecular Weight: 459.45