BAY 61-3606 HYDROCHLORIDE HYDRATE

Application

BAY 61-3606 hydrochloride hydrate has been used in focal cerebral ischemia model. It has also been used to assess the effect of Syk in stroke-induced injury.

Biochem/physiol Actions

BAY 61-3606 helps to prevent the degranulation of freshly isolated basophils. It also prevents B cell receptor (BCR)-mediated signaling.

Spleen tyrosine kinase (Syk) inhibitor; anti-inflammatory. Syk plays a major role in inflammation pathways via receptors for the Fc portion of immunoglobulins, as well as B cell signaling. It is orally active, potent (Ki 7.5 nM), and highly selective for Syk vs other kinases (Lyn, Fyn, Src, Itk, Btk; Ki′s).

Features and Benefits

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound was developed by Bayer. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Molecular Weight: 390.40 (anhydrous free base basis). Empirical Formula: C₂₀H₁₈N₆O₃ · xHCl · yH₂O. Quality Level: 100. Assay: ≥. 98% (HPLC). form: powder. potency: 7.5 . nM K_i. storage condition: desiccated. color: yellow. solubility: H₂O: soluble. originator: Bayer. storage temp.: 2-8°C. SMILES string: O.Cl.COc1ccc(cc1OC)-c2cc3nccn3c(Nc4ncccc4C(N): O)n2. InChI: 1S/C20H18N6O3.ClH.H2O/c1-28-15-6-5-12(10-16(15)29-2)14-11-17-22-8-9-26(17)20(24-14)25-19-13(18(21)27)4-3-7-23-19. . /h3-11H,1-2H3,(H2,21,27)(H,23,24,25). 1H. 1H2. InChI key: WYXPKEXHEJAVSI-UHFFFAOYSA-N. Storage Class Code: 11 - Combustible Solids. WGK: WGK 3. Flash Point(F): Not applicable. Flash Point(C): Not applicable. Personal Protective Equipment: Eyeshields, Gloves, type N95 (US).