InformationBAY 2402234 BAY 2402234 is a novel and selective dihydroorotate dehydrogenase (DHODH) inhibitor with an IC50 of 1.2 nM.TargetsDHODH (Cell-free assay) 1.2 nMIn vitroBAY 2402234 induces differentiation and inhibits proliferation in AML cell lines across multiple AML subtypes.In vivoBAY 2402234 shows strong monotherapy efficacy and induces differentiation in AML xenograft models in vivo.Cell Research(from reference)Cell lines:MOLM-13, HEL, MV4-11, SKM-1 and THP-1 cell lines Concentrations:0.1nM to 1μM Incubation Time:96 h.
Specifications and Purity: 10mM in DMSO
Molecular Formula: C21H18ClF5N4O4
Molecular Weight: 520.84
PubChem CID: 134470179
Isomeric SMILES: CCN1C(=NN(C1=O)C2=C(C=C(C(=C2)O[C@@H](C)C(F)(F)F)C(=O)NC3=C(C=CC=C3Cl)F)F)CO
- UPC:
- 42295101
- Condition:
- New
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- B422666-1ml
- CAS:
- 2225819-06-5
- Product Size:
- 1ml
akash.verma@cenmed.com
(732) 447-1115





