BACITRACIN ZINC (C005B-017240)

General description

Chemical structure: peptide

Application

Bacitracin zinc salt is a peptide antibiotic used to study dysruption of bacterial cell wall synthesis at the level of peptidoglycan biosynthesis and isoprenyl metabolism. It is used to study the biosynthesis of sterols and squalene.

Biochem/physiol Actions

Bacitracin is a protease inhibitor. Antimicrobial spectrum: Gram-positive bacteria.
Mode of Action: Inhibits bacterial cell wall synthesis by inhibiting dephosphorylation of lipid pyrophosphate.

Other Notes

Keep container tightly closed in a dry and well-ventilated place.

Molecular Weight: 1486.07. Empirical Formula: C₆₆H₁₀₁N₁₇O₁₆SZn. biological source: Bacillus licheniformis. Quality Level: 200. form: powder. specific activity: ~70,000 . U/g. mp: 250 . °C (dec.) (lit.). antibiotic activity spectrum: Gram-positive bacteria. Mode of action: cell wall synthesis | interferes. storage temp.: 2-8°C. SMILES string: [Zn++].CCC(C)C(N)C1: NCC(S1)C(: O)N[C@@H](CC(C)C)C(: O)N[C@H](CCC([O-]): O)C(: O)N[C@@H]([C@@H](C)CC)C(: O)N[C@H]2CCCCNC(: O)[C@H](CC(N): O)NC(: O)[C@@H](CC([O-]): O)NC(: O)[C@H](Cc3cnc[nH]3)NC(: O)[C@@H](Cc4ccccc4)NC(: O)[C@@H](NC(: O)[C@@H](CCCN)NC2: O)[C@@H](C)CC. InChI: 1S/C66H103N17O16S.Zn/c1-9-35(6)52(69)66-72-32-48(100-66)63(97)80-43(26-34(4)5)59(93)75-42(22-23-50(85)86)58(92)83-53(36(7)10-2)64(98)76-40-20-15-16-25-71-55(89)46(29-49(68)84)78-62(96)47(30-51(87)88)79-61(95)45(28-39-31-70-33-73-39)77-60(94)44(27-38-18-13-12-14-19-38)81-65(99)54(37(8)11-3)82-57(91)41(21-17-24-67)74-56(40)90. /h12-14,18-19,31,33-37,40-48,52-54H,9-11,15-17,20-30,32,67,69H2,1-8H3,(H2,68,84)(H,70,73)(H,71,89)(H,74,90)(H,75,93)(H,76,98)(H,77,94)(H,78,96)(H,79,95)(H,80,97)(H,81,99)(H,82,91)(H,83,92)(H,85,86)(H,87,88). /q. +2/p-2/t35?,36-,37-,40-,41+,42+,43-,44+,45-,46-,47+,48?,52?,53-,54-. /m0./s1. InChI key: NKULICGUDKGGRL-FCHFGNCGSA-L. Storage Class Code: 11 - Combustible Solids. WGK: WGK 3. Flash Point(F): Not applicable. Flash Point(C): Not applicable. Personal Protective Equipment: Eyeshields, Gloves, type N95 (US).