ARTESUNATE (C005B-086207)

General description

Artesunate is a semisynthetic derivative of artemisinin used to treat malaria. It has also been shown to effective against other parasites such as liver flukes. Artesunate also demonstrates cytotoxic action against cancer cell lines of different tumor types.

Biochem/physiol Actions

Artesunate acts on the electron transport chain, generates local reactive oxygen species, and causes the depolarization of the mitochondrial membrane. It inhibits TNFα-induced production of proinflammatory cytokines via inhibition of NF-κB and PI3 kinase/Akt signal pathway in human rheumatoid arthritis fibroblast-like synoviocytes.

Other Notes

Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.

Molecular Weight: 384.42. Empirical Formula: C₁₉H₂₈O₈. biological source: Artemisia annua. Quality Level: 100. form: crystalline powder. color: white to off-white. solubility: acetone: 33.4 . mg/mL. antibiotic activity spectrum: neoplastics, parasites. Mode of action: protein synthesis | interferes. storage temp.: room temp. InChI: 1S/C19H28O8/c1-10-4-5-13-11(2)16(23-15(22)7-6-14(20)21)24-17-19(13)12(10)8-9-18(3,25-17)26-27-19/h10-13,16-17H,4-9H2,1-3H3,(H,20,21)/t10-,11-,12+,13+,16+,17-,18?,19-/m1/s1. InChI key: FIHJKUPKCHIPAT-JQXDXKTESA-N. Pictograms: GHS07. Signal Word: Warning. Hazard Statements: H302 + H312 + H332. Precautionary Statements: P261 - P264 - P280 - P301 + P312 - P302 + P352 + P312 - P304 + P340 + P312. Hazard Classifications: Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral. Storage Class Code: 13 - Non Combustible Solids. WGK: WGK 3. Flash Point(F): Not applicable. Flash Point(C): Not applicable. Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves.