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ard-266

ARD-266 (C007B-326472)

Catalog No.
C007B-326472
Manufacturer No.
A658631-10mg
Manufacturer Name
Aladdin Scientific
Quantity
1
Unit of Measure
EA

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ARD-266 is a highly potent and von Hippel-Lindau E3 ligase-based Androgen Receptor ( AR ) PROTAC degrader. ARD-266 effectively induces degradation of AR protein in AR -positive LNCaP, VCaP, and 22Rv1 prostate cancer cell lines with DC 50 values of

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ARD-266 is a highly potent and von Hippel-Lindau E3 ligase-based Androgen Receptor ( AR ) PROTAC degrader. ARD-266 effectively induces degradation of AR protein in AR -positive LNCaP, VCaP, and 22Rv1 prostate cancer cell lines with DC 50 values of 0.2-1 nAppearance:SolidIC50& Target:VHLIn Vitro:ARD-266 (Compound 11; 100 nM; 1-24 hours; LNCaP and VCaP cells) treatment effectively reduces the AR protein level within 3 h and achieves near-complete AR elimination with a 6 h treatment in the LNCaP cells. ARD-266 (Compound 11; 1-10000 nM; 24 hourBiological Activity:ARD-266 is a highly potent and von Hippel-Lindau E3 ligase-based Androgen Receptor ( AR ) PROTAC degrader. ARD-266 effectively induces degradation of AR protein in AR -positive LNCaP, VCaP, and 22Rv1 prostate cancer cell lines with DC 50 values of 0.2-1 n.

Specifications and Purity: ≥99%

Molecular Formula: C52H59ClN6O7

Molecular Weight: 915.51

UPC:
41113405
Condition:
New
HazmatClass:
No
WeightUOM:
LB
MPN:
A658631-10mg
Product Size:
10mg

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