ANTI-TUSC3 ANTIBODY PRODUCED IN RABBIT (C005B-475514)

General description

Tumor suppressor candidate 3 (TUSC3) codes for a subunit of the endoplasmic reticulum-bound oligosaccharyltransferase complex. It is a 348 amino acid protein, that has 11 exons spanning ∼224 Kbp of the genomic DNA. TUSC3 has five potential transmembrane domains and is located on human chromosome 8p22.

Immunogen

The antiserum was produced against synthesized peptide derived from human TUSC3.

Immunogen Range: 131-180

Application

Anti-TUSC3 antibody has been used in immunohistochemistry, immunoblotting and co-immunoprecipitation.

Biochem/physiol Actions

Tumor suppressor candidate 3 (TUSC3) is a tumor suppressor gene, that is responsible for autosomal recessive mental retardation. It participates in catalyzing the transfer of a 14-sugar oligosaccharide from dolichol to nascent protein. Absence of TUSC3 is associated with lymph node metastasis in larynx and pharynx squamous cell carcinomas.

Features and Benefits

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Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.