ANTI-PHOSPHO-TRK C (PTYR516)ANTIBODY PRODUCED IN RABBIT

General description

Neurotrophic receptor tyrosine kinase 3 (NTRK3), also known as tropomyosin receptor kinase C (TRKC), with 20 exons and 19 introns, is mapped to human chromosome 15q25. NTRK3 encodes the high-affinity receptor for neurotrophin 3 (NT-3). The encoded 145kDa glycoprotein belongs to tropomyosin-related kinase (Trk) family of neurotrophin receptors. NTRK3 is characterized with a signal sequence, two cysteine-rich domains flanking a leucine-rich domain, two Ig-like domains of the C2 type, a transmembrane domain and a tyrosine kinase domain.

Immunogen

The antiserum was produced against synthesized peptide derived from human Trk C around the phosphorylation site of Tyr516.

Immunogen Range: 482-531

Biochem/physiol Actions

Neurotrophic receptor tyrosine kinase 3 (NTRK3) plays a vital role in regulation of cell proliferation, survival and differentiation in the mammalian nervous system, especially those of sensory neurons involved in proprioception. It is also involved in the formation of the mammalian heart. TRKC facilitates initiation, progression and metastasis of many tumors in humans. TRKC is overexpressed in neuroblastomas as well as medulloblastomas and also in various non-neuronal tissues including medullary thyroid carcinoma, breast cancer, colon cancer, lung cancer, liver cancer, prostate cancer. The encoded protein acts as a receptor for the neurotrophin 3′-nucleotidase (NT3), which is involved in oligodendrocyte and myelin formation. Variation in the gene affects white matter integrity in brain regions associated with neuropsychiatric disorders, including major depressive disorder (MDD-RE). TRKC stimulates the expression of serine/threonine-protein kinase PLK-1 and Twist-1 transcription factor via activation of Akt (a serine/threonine kinase also known as protein kinase B [PKB]) / mammalian (or mechanistic) target of rapamycin (mTOR) pathway and inhibits apoptosis. Thus, it facilitates leukemogenesis.

Features and Benefits

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Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.