ANTI-INTEGRIN ALPHA 4 ANTIBODY RABBIT MONOCLONAL

General description

Integrin subunit α4 (ITGA4) is an adhesive factor, that is part of the integrin family. The gene encoding it is localized on human chromosome 2q31.3.

Specificity

This antibody reacts to the cytoplasmic domain of human Integrin alpha 4 (ITGA4).

Immunogen

Synthetic peptide corresponding to the C-terminus of human Integrin alpha 4 (ITGA4)

Biochem/physiol Actions

Integrin subunit α 4 (ITGA4) has a role in bone marrow homing. It associates with the β1 integrin chain and forms the very-late-antigen-4 (VLA-4) complex. The protein also binds to vascular cell adhesion molecule-1, fibronectin and osteopontin (OPN) and modulates the activity of immature progenitors in the bone marrow. ITGA4 also aids the migration of B lymphocytes through the fibroblast barrier.

Features and Benefits

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Physical form

Solution in phosphate buffered saline containing 50% glycerol, 1% BSA and 0.09% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.