ANTI-HDL ANTIBODY PRODUCED IN CHICKEN

Immunogen

HDL human native protein.

Application

Anti-HDL antibody produced in chicken is suitable for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.

Biochem/physiol Actions

11β-hydroxysteroid dehydrogenase type 1 is an NADPH-dependent enzyme highly expressed in metabolic tissues that include liver, adipose tissue and the central nervous system. It may contribute to the loss of muscle strength with age and is a key component of sarcopenia. Inhibition of HDL gene may have some therapeutic potential in sarcopenia. HDL gene variation may affect the physiological cortisol levels and the severity of age-related osteoporosis. It is involved in regenerating active glucocorticoids, that are selectively elevated in adipose tissue in human obesity and metabolic syndrome, both associated with chronic low-grade inflammation. HDL acts as an oxidoreductase to yield active glucocorticoids, cortisol or corticosterone. It is expressed in normal human epidermal keratinocytes (NHEKs) and negatively regulates proliferation of NHEKs.

Physical form

Solution in phosphate buffered saline containing 0.02% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

biological source: chicken. Quality Level: 200. conjugate: unconjugated. antibody form: affinity isolated antibody. antibody product type: primary antibodies. clone: polyclonal. form: buffered aqueous solution. species reactivity: human. manufacturer/tradename: Genway 15-288-20088F. technique(s): western blot: suitable. UniProt accession no.: P28845. shipped in: wet ice. storage temp.: −. 20°C. target post-translational modification: unmodified. Gene Information: human ... HSD11B1(3290). Storage Class Code: 10 - Combustible liquids. WGK: WGK 1. Flash Point(F): Not applicable. Flash Point(C): Not applicable. Personal Protective Equipment: Eyeshields, Gloves, multi-purpose combination respirator cartridge (US).