AMENTOFLAVONE >=99.0% HPLC (C005B-020791)

General description

Amentoflavone is a naturally occurring polyphenolic biflavonoid found in many plants. Structurally, it has an apigenin dimer which is linked by a C3′-C8′′ covalent bond.

Application

Amentoflavone has been used:

• as a chemical inhibitor to determine the selective attenuation of p-Cresol glucuronidation in HepaRG cells
• as a reference standard for qualitative and quantitative analyses of phenolic compounds of Juniperus foetidissima Willd. and Juniperus sabina L. using reverse phase- high-performance liquid chromatography- diode array detector (RP-HPLC-DAD)
• as a reference standard to analyze and standardize the methanol extract process of Juniperus drupacea Labill. phenolic compounds using reverse phase- high-performance liquid chromatography - diode array detector (RP-HPLC-DAD)

Biochem/physiol Actions

Amentoflavone has various pharmacological properties such as antioxidant, anti-diabetic, anti-tumor, anti-senescence, neuroprotective, and cardioprotective activities.

Biflavonoid with anti-inflammatory, anti-viral and cancer chemopreventive activity. It inhibits vascularization of tumors by blocking the activity of angiogenic VEGFs. Blocks the induction of COX-2 and up-regulates PPAR-γ. It is a negative modulator of the GABA_A receptor at the benzodiazepine binding site.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Molecular Weight: 538.46. Empirical Formula: C₃₀H₁₈O₁₀. Quality Level: 100. Assay: ≥. 98.0% (HPLC). form: solid. application(s): metabolomics
vitamins, nutraceuticals, and natural products. storage temp.: 2-8°C. SMILES string: Oc1ccc(cc1)C2: CC(: O)c3c(O)cc(O)c(c3O2)-c4cc(ccc4O)C5: CC(: O)c6c(O)cc(O)cc6O5. InChI: 1S/C30H18O10/c31-15-4-1-13(2-5-15)24-12-23(38)29-21(36)10-20(35)27(30(29)40-24)17-7-14(3-6-18(17)33)25-11-22(37)28-19(34)8-16(32)9-26(28)39-25/h1-12,31-36H. InChI key: YUSWMAULDXZHPY-UHFFFAOYSA-N. Gene Information: human ... GABRA1(2554). Storage Class Code: 11 - Combustible Solids. WGK: WGK 3. Flash Point(F): Not applicable. Flash Point(C): Not applicable. Personal Protective Equipment: Eyeshields, Gloves, type N95 (US).