Amelubant (BIIL 284) is a potent, oral and long acting LTB 4 receptor antagonist, negligibly binds to LTB 4 receptor, with K i s of 221 nM and 230 nM in vital cells and membranes. Amelubant (BIIL 284) is a proagent of active metabolites BIIL 260 and BIIL 315. Anti-inflammatory activityIn VitroAmelubant is a prodrug of active metabolites BIIL 260 and BIIL 315, which are reversible and competitive LTB 4 receptor antagonists, with K i s of 1.4, 1.1 nM and 1.7, 1.9 nM in vital cells and membranes, respectively. MCE has not independently confirmed the accuracy of these methods. They are for reference only.IC50& Target:LTB 4 221 nM (Ki, in vital human granulocytes) LTB 4 230 nM (Ki, in cell membranes).
Specifications and Purity: 10mM in DMSO
Molecular Formula: C33H34N2O5
Molecular Weight: 538.63
- UPC:
- 42272017
- Condition:
- New
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- A656235-1ml
- CAS:
- 346735-24-8
- Product Size:
- 1ml
akash.verma@cenmed.com
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