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alpelisib (byl719)

Alpelisib (BYL719)

Catalog No.
C007B-020289
Manufacturer No.
A408653-1ml
Manufacturer Name
Aladdin Scientific
Quantity
1
Unit of Measure
EA

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InformationAlpelisib (BYL719) is a potent and selectivePI3Kαinhibitor withIC50of 5 nM in a cell-free assay, and minimal effect on PI3Kβ/γ/δ. Phase 2.In vitroBYL719 inhibits the proliferation of breast cancer cell lines harboring PIK3CA mutations,

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InformationAlpelisib (BYL719) is a potent and selectivePI3Kαinhibitor withIC50of 5 nM in a cell-free assay, and minimal effect on PI3Kβ/γ/δ. Phase 2.In vitroBYL719 inhibits the proliferation of breast cancer cell lines harboring PIK3CA mutations, correlating with inhibition of various downstream signaling components of the PI3K/Akt pathway.In vivoBYL719(>270 mg/d) shows statistically significant dose-dependent anti-tumor efficacy in PIK3CA mutant xenograft models in rodents. BYL719 has a low clearance, a half-life of 8.5 h and its exposure increases dose proportionally between 30mg/d and 450mg/d, displaying a low inter-individual variability in Cmax and AUC in human. BYL719(270mg/d) shows first signs of clinical efficacy include 1 confirmed partial response in a patient with ER+ breast cancer, and significant PET responses (PMR) and/or tumor shrinkage are achieved in 8 out of 17 evaluated patients.Cell Datacell lines：Concentrations：Incubation Time：Powder Purity:≥99%.

Specifications and Purity: 10mM in DMSO

Molecular Formula: C19H22F3N5O2S

Molecular Weight: 441.47

UPC:
51101620
Condition:
New
HazmatClass:
No
WeightUOM:
LB
MPN:
A408653-1ml
CAS:
1217486-61-7
Product Size:
1ml

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