ALENDRONATE SODIUM TRIHYDRATE

Application

Alendronate sodium trihydrate has been used:

• for calcium phosphate nanoparticles (nCaP)/ bisphosphonate (BP) coating on titanium implants and analyze its osteogenic capacity
• in osteogenic differentiation of human bone marrow stromal cells (hBMSCs) isolated from aged osteoporosis patients- and healthy-person
• to treat osteoblast progenitor cells and osteoblasts and study their effect on osteoblast behaviors using conventional assays and simple digital image analysis

Biochem/physiol Actions

Alendronate is a nitrogen-containing bisphosphonate that is known to hinder the mevalonate pathway and limit osteoclastic function and activity. Alendronate sodium trihydrate is a bone resorption inhibitor, farnesyl diphosphate synthase inhibitor, and CD45 protein tyrosine phosphatase inhibitor.

Alendronate sodium trihydrate is a bone resorption inhibitor; farnesyl diphosphate synthase inhibitor (IC₅₀ = 460 nM); CD45 protein tyrosine phosphatase inhibitor.

Molecular Weight: 325.12. Empirical Formula: C₄H₁₂NaNO₇P₂ · 3 H₂O. Quality Level: 100. Assay: ≥. 97% (NMR). form: powder. color: white. solubility: water, double-distilled: 10 . mg/mL. storage temp.: −. 20°C. SMILES string: [Na+].[H]O[H].[H]O[H].[H]O[H].NCCCC(O)(P(O)(O): O)P(O)([O-]): O. InChI: 1S/C4H13NO7P2.Na.3H2O/c5-3-1-2-4(6,13(7,8)9)14(10,11)12. . . . /h6H,1-3,5H2,(H2,7,8,9)(H2,10,11,12). . 3*1H2/q. +1. . . /p-1. InChI key: DCSBSVSZJRSITC-UHFFFAOYSA-M. Gene Information: human ... FDPS(2224). Pictograms: GHS07. Signal Word: Warning. Hazard Statements: H302. Precautionary Statements: P264 - P270 - P301 + P312 - P501. Hazard Classifications: Acute Tox. 4 Oral. Storage Class Code: 11 - Combustible Solids. WGK: WGK 3. Flash Point(F): Not applicable. Flash Point(C): Not applicable. Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves.